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Anticholinergics such as atropine, hyoscyamine, and scopolamine antagonize the muscarinic acetylcholine receptors in the eye. By blocking these receptors, the pupils are no longer capable of constriction and dilation results. Such alkaloids present in many plants of the family Solanaceae may also induce mydriasis when used recreationally.[5]
Most hallucinogens such as LSD, psilocybin, and mescaline, in addition to some other phenethylamines and tryptamines, all produce mydriasis by agonizing the serotonergic 5-HT2A receptors in the brain. Dissociatives such as ketamine, DXM, and PCP do so as well via antagonism of the NMDA glutamate receptors. There have also been reports that the atypical psychedelic herb Salvia divinorum and its active constituent salvinorin A causes mydriasis. It works via agonism of the κ-Opioid receptors in the brain. How the neurological changes induced by these drugs ultimately causes pupil dilation is unknown.
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i wanna be
- that girl you tell all your friends about
- the one you have pictures of from facebook to show your friends
- you think about first thing in the morning and right before bed
- the one who gives you butterflies whenever you think of me
- the one who makes you nervous when ever you see me
- the one who can change the mood of your day with hello
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